Effect of certain folic acid antagonists on transplanted myeloid and lymphoid leukemias of the F strain of mice.

Transplanted mouse leukemia is being utilized as a test object for agents now being used in clini cal treatment and as a screen for compounds which might conceivably be employed in the therapy of human leukemia (†̃2, 6, 7). The objective of the present study was to test the influence of certain folic acid antagonists on the course and develop ment of transplanted leukemia which originated in the F strain (9). Aminopterin and amethopterin, agents tested in this investigation, have been re ported to exert significant therapeutic effects on acute leukemia of children and to delay the devel opment of certain transfer lines of mouse leukemia (†̃2—5, 10, 1'2, 15).